Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases.Report as inadecuate




Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases. - Download this document for free, or read online. Document in PDF available to download.

* Corresponding author 1 CRCM - Centre de Recherche en Cancérologie de Marseille 2 Département de biopathologie

Abstract : ABSTRACT: The ASXL1 gene is one of the most frequently mutated genes in malignant myeloid diseases. The ASXL1 protein belongs to protein complexes involved in the epigenetic regulation of gene expression. ASXL1 mutations are found in myeloproliferative neoplasms MPN, myelodysplastic syndromes MDS, chronic myelomonocytic leukemia CMML and acute myeloid leukemia AML. They are generally associated with signs of aggressiveness and poor clinical outcome. Because of this, a systematic determination of ASXL1 mutational status in myeloid malignancies should help in prognosis assessment.

Keywords : ASXL1 Gene mutations Myeloid diseases





Author: Véronique Gelsi-Boyer - Mandy Brecqueville - Raynier Devillier - Anne Murati - Marie-Joelle Mozziconacci - Daniel Birnbaum -

Source: https://hal.archives-ouvertes.fr/



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