Acarbose Accelerates Wound Healing via Akt-eNOS Signaling in db-db MiceReport as inadecuate




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Oxidative Medicine and Cellular Longevity - Volume 2017 2017, Article ID 7809581, 11 pages - https:-doi.org-10.1155-2017-7809581

Research ArticleDepartment of Pharmacy, Xiaoshan Hospital, Hangzhou, Zhejiang 311202, China

Correspondence should be addressed to Guojun Jiang

Received 31 October 2016; Revised 17 January 2017; Accepted 20 February 2017; Published 8 March 2017

Academic Editor: Flávio Reis

Copyright © 2017 Xue Han et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Refractory wound is a dreaded complication of diabetes and is highly correlated with EPC dysfunction caused by hyperglycemia. Acarbose is a widely used oral glucose-lowering drug exclusively for T2DM. Previous studies have suggested the beneficial effect of acarbose on improving endothelial dysfunction in patients with T2DM. However, no data have been reported on the beneficial efficacy of acarbose in wound healing impairment caused by diabetes. We herein investigated whether acarbose could improve wound healing in T2DM db-db mice and the possible mechanisms involved. Acarbose hastened wound healing and enhanced angiogenesis, accompanied by increased circulating EPC number in db-db mice. In vitro, a reversed BM-EPC dysfunction was observed after the administration of acarbose in db-db mice, as reflected by tube formation assay. In addition, a significantly increased NO production was also witnessed in BM-EPCs from acarbose treated db-db mice, with decreased O2 levels. Akt inhibitor could abolish the beneficial effect of acarbose on high glucose induced EPC dysfunction in vitro, accompanied by reduced eNOS activation. Acarbose displayed potential effect in promoting wound healing and improving angiogenesis in T2DM mice, which was possibly related to the Akt-eNOS signaling pathway.





Author: Xue Han, Yaping Deng, Jiawen Yu, Yuannan Sun, Guofei Ren, Jian Cai, Jianjun Zhu, and Guojun Jiang

Source: https://www.hindawi.com/



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