Clear Cell Carcinoma of the Endometrium Causing Paraneoplastic Retinopathy: Case Report and Review of the LiteratureReport as inadecuate




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Case Reports in Obstetrics and GynecologyVolume 2011 2011, Article ID 631929, 4 pages

Case Report

Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON, Canada M5G 0A3

Department of Ophthalmology and Vision Sciences, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada M5G 2M9

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada M5G 2M9

Received 23 May 2011; Accepted 21 June 2011

Academic Editor: J. Higgins

Copyright © 2011 Paulina Cybulska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We reviewed the literature for cases in which gynecologic malignancies caused paraneoplastic retinopathy and ultimately led to blindness. Twenty-eight cases were derived from the literature, and one unique case is described from our institution. Of these 28 cases, 14 patients were diagnosed with endometrial cancer, 7 with ovarian cancer, 5 with cervical cancer, 1 fallopian tube cancer and 1 with concomitant endometrial and ovarian cancers. The average age of patients at the time of diagnosis was 64 years range, 35–89 years. Typically, ocular manifestations antedate symptoms of the underlying carcinoma by 3–12 months. Information regarding the interval from visual symptoms to time of death is limited, but ranges from several months to several years. Our report is the first to document a clear cell carcinoma of the endometrium causing paraneoplastic retinopathy and is the first to review all gynecologic malignancies associated with visual paraneoplastic syndromes.





Author: Paulina Cybulska, Eduardo V. Navajas, Filiberto Altomare, and Marcus Q. Bernardini

Source: https://www.hindawi.com/



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