Oxidative Stress and Immune System in Vitiligo and Thyroid DiseasesReport as inadecuate




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Oxidative Medicine and Cellular Longevity - Volume 2015 2015, Article ID 631927, 7 pages -

Review ArticleSection of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Ospedale Piero Palagi, Viale Michelangelo 41, 50125 Florence, Italy

Received 24 December 2014; Accepted 2 March 2015

Academic Editor: Thomas Kietzmann

Copyright © 2015 Roberta Colucci et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Vitiligo is an acquired dermatological disease frequently associated with autoimmune thyroid disorders. Several theories have been proposed so far to unravel the complex vitiligo pathogenesis. Currently, the autocytotoxic and the autoimmune theories are the most accredited hypothesis, since they are sustained by several important clinical and experimental evidences. A growing body of evidences shows that autoimmunity and oxidative stress strictly interact to finally determine melanocyte loss. In this scenario, associated thyroid autoimmunity might play an active and important role in triggering and maintaining the depigmentation process of vitiligo.





Author: Roberta Colucci, Federica Dragoni, and Silvia Moretti

Source: https://www.hindawi.com/



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