The Fetal Allograft Revisited: Does the Study of an Ancient Invertebrate Species Shed Light on the Role of Natural Killer Cells at the Maternal-Fetal InterfaceReport as inadecuate




The Fetal Allograft Revisited: Does the Study of an Ancient Invertebrate Species Shed Light on the Role of Natural Killer Cells at the Maternal-Fetal Interface - Download this document for free, or read online. Document in PDF available to download.

Clinical and Developmental ImmunologyVolume 2008 2008, Article ID 631920, 10 pages

Review Article

School of Medicine, Boston University, 715 Albany Street, Boston, MA 02118, USA

Department of Obstetrics, Gynecology and Women's Health, School of Medicine, University of Missouri-Columbia, Columbia, MO 65201, USA

Department of Medicine, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA

Received 15 February 2008; Accepted 12 May 2008

Academic Editor: Ronald Herberman

Copyright © 2008 Amy Lightner et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Human pregnancy poses a fundamental immunological problem because the placenta and fetus are genetically different from the host mother. Classical transplantation theory has not provided a plausible solution to this problem. Study of naturally occurring allogeneic chimeras in the colonial marine invertebrate, Botryllus schlosseri, has yielded fresh insight into the primitive development of allorecognition, especially regarding the role of natural killer NK cells. Uterine NK cells have a unique phenotype that appears to parallel aspects of the NK-like cells in the allorecognition system of B. schlosseri. Most notably, both cell types recognize and reject “missing self” and both are involved in the generation of a common vascular system between two individuals. Chimeric combination in B. schlosseri results in vascular fusion between two individual colonies; uterine NK cells appear essential to the establishment of adequate maternal-fetal circulation. Since human uterine NK cells appear to de-emphasize primary immunological function, it is proposed that they may share the same evolutionary roots as the B. schlosseri allorecognition system rather than a primary origin in immunity.





Author: Amy Lightner, Danny J. Schust, Yi-Bin A. Chen, and Breton F. Barrier

Source: https://www.hindawi.com/



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