The Dynamic Optical Breast Imaging in the Preoperative Workflow of Women with Suspicious or Malignant Breast Lesions: Development of a New Comprehensive ScoreReport as inadecuate




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ISRN OncologyVolume 2012 2012, Article ID 631917, 9 pages

Research Article

Department of Breast Disease, National Cancer Institute “G. Pascale” Foundation, Via Mariano Semmola, 80136 Naples, Italy

Department of Radiology, National Cancer Institute “G. Pascale” Foundation, Via Mariano Semmola, 80136 Naples, Italy

Breast Unit, Clinical Institute Zucchi, Via Zucchi 24, 20052 Monza, Italy

Breast Unit, Clinical Institute Pio X, Via Francesco Nava 31, 20159 Milano, Italy

Breast Surgery Divison, Medical Institute Monterosa, Via Monterosa 3, 20149 Milano, Italy

Breast Prevention Area, Physios Clinic, Via Chiesa Nord 52, 41016 Modena, Italy

Epidemiology Division, National Cancer Institute “G. Pascale” Foundation, Via Mariano Semmola, 80136 Naples, Italy

National Cancer Institute “G. Pascale” Foundation, Via Mariano Semmola, 80136 Naples, Italy

Received 19 June 2012; Accepted 29 July 2012

Academic Editors: M. Loizidou and Y. Yu

Copyright © 2012 Massimiliano D-Aiuto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To determine the diagnostic accuracy of DOBIComfortScan in patients with Breast Imaging Reporting suspect breast lesions BI-RADS 4-5 breast lesions. Materials and Methods. One-hundred and thirteen patients underwent DOBIComfortScan examination before surgery. Twelve parameters were taken into consideration to define DOBI findings. Results. Twenty-seven radical mastectomies, 47 quadrantectomies and 39 wide excisions, were performed. Overall, 65 invasive cancer, 9 in situ carcinoma and 39 nonmalignant lesions, were observed. Ten out of 12 considered parameters resulted significantly in association with histology at discriminant analysis. A summation score of 30.5 resulted to be the best cut off at ROC analysis, giving a sensitivity and specificity of 80% and 87%, respectively, and a positive predictive value of 92.2%. Finally the following DOBI-BI-RADS model was developed: malignant score; possibly malignant score; benign but the possibility of malignancy cannot be excluded score; benign score. Conclusion. definition of other parameters permits to improve the accuracy of this procedure. Further studies are warranted to define the potential role of DOBIComfortScan in breast cancer imaging.





Author: Massimiliano D-Aiuto, Giuseppe Frasci, Maria Luisa Barretta, Adolfo Gallipoli, Giovanni Maria Ciuffo, Flavia Musco, Sergio O

Source: https://www.hindawi.com/



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