Proinflammatory and Prothrombotic State in Subjects with Different Glucose Tolerance Status before Cardiovascular DiseaseReport as inadecuate




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Journal of Diabetes ResearchVolume 2014 2014, Article ID 631902, 9 pages

Research Article

Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, H.G.R. No. 1 “Dr. Carlos Mac Gregor Sánchez Navarro” Instituto Mexicano del Seguro Social, Apartado Postal B 32, Coahuila No. 5, 06703 México, DF, Mexico

Servicio de Medicina Interna, UMAE, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, 06720 México, DF, Mexico

Unidad de Investigación Médica en Medicina Reproductiva, UMAE H.G.O. No. 4, Instituto Mexicano del Seguro Social, 01070 México, DF, Mexico

Servicio de Medicina Interna, H.G.Z. A 2 “Francisco del Paso y Troncoso”, del Instituto Mexicano del Seguro Social, 08400 México, DF, Mexico

Servicio de Medicina Interna, H.G.R. No. 1 “Dr. Carlos Mac Gregor Sánchez Navarro” Instituto Mexicano del Seguro Social, 03100 México, DF, Mexico

Servicio de Urgencias, H.G.R. No. 1 “Dr. Carlos Mac Gregor Sánchez Navarro” Instituto Mexicano del Seguro Social, 03100 México, DF, Mexico

Received 2 October 2013; Accepted 22 January 2014; Published 17 March 2014

Academic Editor: Joseph Fomusi Ndisang

Copyright © 2014 Irma Isordia-Salas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Inflammation has been associated with insulin resistance, type 2 diabetes mellitus T2DM, and atherothrombosis. Aim. To determine differences in levels of proinflammatory and prothrombotic markers such as high sensitivity C-reactive protein hs-CRP and fibrinogen in subjects with normal glucose tolerance NGT, prediabetes, and T2DM and to establish their relationship with other cardiovascular risk factors before clinical manifestations of cardiovascular disease. Methods. We conducted a nonrandomized, cross-sectional assay in a hospital at México City. The levels of hs-CRP and fibrinogen were measured and compared according to glucose tolerance status. Results. We enrolled 1047 individuals and they were distributed into NGT , pre-DM , and T2DM . There was a statistical difference between NGT and T2DM groups for fibrinogen and hs-CRP . Fibrinogen and hs-CRP showed a significant positive correlation coefficient , . In a multiple stepwise regression analysis, the variability in fibrinogen levels was explained by age, HbA1c, and hs-CRP adjusted , , and for hs-CRP it was explained by BMI and fibrinogen adjusted , . Conclusion. Inflammation and prothrombotic state are present in people with T2DM lacking cardiovascular disease. Fibrinogen and Hs-CRP are positively correlated. Fibrinogen and hs-CRP concentrations are predominantly determined by BMI rather than glucose levels.





Author: Irma Isordia-Salas, María Eugenia Galván-Plata, Alfredo Leaños-Miranda, Eberth Aguilar-Sosa, Francisco Anaya-Gómez, Abrah

Source: https://www.hindawi.com/



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