Effectiveness of Intermittent Preventive Treatment in Pregnancy with Sulphadoxine-Pyrimethamine against Submicroscopic falciparum Malaria in Central Region, GhanaReport as inadecuate




Effectiveness of Intermittent Preventive Treatment in Pregnancy with Sulphadoxine-Pyrimethamine against Submicroscopic falciparum Malaria in Central Region, Ghana - Download this document for free, or read online. Document in PDF available to download.

Journal of Parasitology Research - Volume 2015 2015, Article ID 959427, 6 pages -

Research Article

Vector Genetics Laboratory, Biotechnology and Nuclear Agriculture Research Institute, Ghana Atomic Energy Commission, Accra, Ghana

Department of Biomedical and Forensic Sciences, University of Cape Coast, Cape Coast, Ghana

Department of Internal Medicine, Effia-Nkwanta Regional Hospital Sekondi-Takoradi, Sekondi, Western Region, Ghana

Received 28 May 2015; Revised 21 August 2015; Accepted 30 August 2015

Academic Editor: Xin-zhuan Su

Copyright © 2015 Ekene K. Nwaefuna et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Malaria infections undetectable by microscopy but detectable by Polymerase Chain Reaction PCR submicroscopic malaria are common in endemic areas like Ghana. Submicroscopic malaria has been linked with severe pregnancy outcomes as well as contributing to malaria transmission. In this cross-sectional study 872 consenting pregnant women gestation ≥ 20 weeks were recruited from 8 hospitals in Central Region, Ghana, between July and December 2009. Malaria infection was detected by microscopy and PCR. Haemoglobin was measured and anaemia was defined as haemoglobin lower than 11 g-dL. Majority of the women, 555 63.6%, were Intermittent Preventive Treatment in Pregnancy with Sulphadoxine-Pyrimethamine IPTp-SP users while 234 36.4% were nonusers. The prevalence of malaria by microscopy was 20.9% 182-872 and 9.7% 67-688 of microscopy negative women had submicroscopic malaria. IPTp-SP usage significantly odds ratio = 0.13, 95% confidence interval = 0.07–0.23, reduced the prevalence of submicroscopic malaria as more nonusers 51-234 than users 16-454 were PCR positive. After controlling for other variables the effect of IPTp-SP remained statistically significant odds ratio = 0.11, 95% confidence interval = 0.02–0.22, . These results suggest that Intermittent Preventive Treatment with Sulphadoxine-Pyrimethamine is useful in the reduction of submicroscopic malaria in pregnancy.





Author: Ekene K. Nwaefuna, Richmond Afoakwah, Verner N. Orish, Alexander Egyir-Yawson, and Johnson N. Boampong

Source: https://www.hindawi.com/



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