Myxoma virus in the European rabbit: interactions between the virus and its susceptible hostReport as inadecuate




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Abstract : Myxoma virus MV is a poxvirus that evolved in Sylvilagus lagomorphs, and is the causative agent of myxomatosis in European rabbits Oryctolagus cuniculus. This virus is not a natural pathogen of O. cuniculus, yet is able to subvert the host rabbit immune system defenses and cause a highly lethal systemic infection. The interaction of MV proteins and the rabbit immune system has been an ideal model to help elucidate host-poxvirus interactions, and has led to a greater understanding of how other poxvirus pathogens are able to cause disease in their respective hosts. This review will examine how MV causes myxomatosis, by examining a selection of the identified immunomodulatory proteins that this virus expresses to subvert the immune and inflammatory pathways of infected rabbit hosts.

keyword : myxoma virus immunomodulation poxvirus Oryctolagus cuniculus





Author: Marianne Stanford Steven Werden Grant Mcfadden

Source: https://hal.archives-ouvertes.fr/



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