Evaluation of humoral immune status in porcine epidemic diarrhea virus PEDV infected sows under field conditionsReport as inadecuate




Evaluation of humoral immune status in porcine epidemic diarrhea virus PEDV infected sows under field conditions - Download this document for free, or read online. Document in PDF available to download.

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Abstract : AbstractPorcine epidemic diarrhea virus PEDV is an economically devastating enteric disease in the swine industry.
The virus infects pigs of all ages, but it cause severe clinical disease in neonatal suckling pigs with up to 100% mortality.
Currently, available vaccines are not completely effective and feedback methods utilizing PEDV infected material has variable success in preventing reinfection.
Comprehensive information on the levels and duration of effector-memory IgA and IgG antibody secreting B cell response in the intestines and lymphoid organs of PEDV-infected sows, and their association with specific antibody levels in clinical samples such as plasma, oral fluid, and feces is important.
Therefore, our goal in this study was to quantify PEDV specific IgA and IgG B cell responses in sows at approximately 1 and 6 months post-infection in commercial swine herds, including parity one and higher sows.
Our data indicated that evaluation of both PEDV specific IgA and IgG antibody levels in the plasma and oral fluid but not feces samples is beneficial in disease diagnosis.
PEDV specific B cell response in the intestine and spleen of infected sows decline by 6 months, and this associates with specific antibody levels in the plasma and oral fluid samples; but the virus neutralization titers in plasma remains high beyond 6 months post-infection.
In conclusion, in sows infected with PEDV the presence of effector-memory B cell response and strong virus neutralization titers in plasma up to 6 months post-infection, suggests their potential to protect sows from reinfection and provide maternal immunity to neonates, but challenge studies are required to confirm such responses.






Author: Kang Ouyang Duan-Liang Shyu Santosh Dhakal Jagadish Hiremath Basavaraj Binjawadagi Yashavanth S.
Lakshmanappa Rui Guo Russell Ran


Source: https://hal.archives-ouvertes.fr/



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