en fr Peripheral arterial disease in Central Africa : Epidemiology, risk factors, marker prognostic Artériopathie oblitérante des membres inférieurs en Afrique Centrale : Epidémiologie, facteurs de risque, marqueur pronostiquReport as inadecuate




en fr Peripheral arterial disease in Central Africa : Epidemiology, risk factors, marker prognostic Artériopathie oblitérante des membres inférieurs en Afrique Centrale : Epidémiologie, facteurs de risque, marqueur pronostiqu - Download this document for free, or read online. Document in PDF available to download.

1 NET - Neuroépidémiologie Tropicale

Abstract : With the aging of the global population, the prevalence of non-communicable, including cardiovascular, diseases is increasing.
While epidemiological studies on peripheral artery disease PAD have been mainly conducted in high-income countries, a few have been carried out in low-and middle-income countries, including in Africa.
EPIDEMCA Epidemiology of Dementia in Central Africa is a cross-sectional population-based study in rural and urban areas of two countries of Central Africa: Central African Republic CAR and the Republic of Congo ROC.
Overall, its aim was to investigate the health status in aging population in Central Africa, with a special focus on cognitive disorders, PAD Ankle-Brachial Index ABI ≤0.90.
and cardiovascular risk factors as well as their inter-relationship.
The EPIDEMCA program was carried out, among people aged 65 years and over, between 2011 and 2012.
Among 2002 subjects who agreed to participate, reliable demographic and vascular data were available in 1871 subjects.Overall, the prevalence of PAD was 14.8% reachting 22.2% after the age of 80.
The prevalence was higher in ROC than in CAR 17.4% vs.
12.2%, p=0.0071 and in females than males 16.6% vs.
11.9%, p=0.0122.
Higher rates of PAD were found in urban area in ROC 20.7% vs.
14.4% in rural area, p=0.0114, not in CAR 11.5% vs.
12.9%, p=ns.
In the multivariate analysis, PAD significantly associated factors were described: age OR: 1.03; p=0.0039, dyslipidemia OR: 1.88; p=0.0034, smoking OR: 1.78; p=0.0026, and more specifically undernutrition OR: 2.09, p=0.0009.
Undernutrition was still significantly associated with PAD after adjustment to all potential confounding factors in males as well as in females OR: 2.82, p= 0.0038 respectively OR: 1.75, p= 0.0492.
As epidemiological research on the implication of atherosclerosis in the development of cognitive impairment in general population is lacking in Africa, we focused on the role of ABI as an available marker of atherosclerosis, providing independent and incremental information on subjects’ susceptibility to present cognitive disorders.The prevalence of cognitive impairment among the study participants was 13.6%, higher in subjects with ABI≤0.9 and ABI≥1.4 than those with 0.9



Author: Ileana Sepeteanu Desormais -

Source: https://hal.archives-ouvertes.fr/



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