Prevalence of Joint Hypermobility and Patterns of Articular Manifestations in Patients with Inflammatory Bowel DiseaseReport as inadecuate




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Gastroenterology Research and PracticeVolume 2009 2009, Article ID 924138, 5 pages

Research Article

Endoscopy Unit & Inflammatory Bowel Diseases Unit, University General Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis 68100, Greece

1st Surgical Department, University General Hospital of Alexandroupolis, Democritus University of Thrace, Dragana, Alexandroupolis 68100, Greece

2nd Surgical Department, University General Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis 68100, Greece

2nd Department of Internal Medicine, University General Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis 68100, Greece

Received 6 July 2009; Revised 11 November 2009; Accepted 10 December 2009

Academic Editor: Paolo Gionchetti

Copyright © 2009 P. Vounotrypidis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. The objective is the investigation of Joint Hypermobility JH and the Hypermobility Syndrome HMS in patients with inflammatory bowel disease IBD. Methods. We examined 83 patients with IBD and 67 healthy individuals for the presence of JH. Patients were excluded if they were under 18 or over 50 years of age and if they had other conditions which affect joint mobility. The and the Fisher exact test were used appropriately between study groups. Odds ratios ORs for the risk of JH and HMS in IBD groups were calculated. Results. A total of 150 individuals 83 IBD patients and 67 healthy controls participated in the study. 69 IBD patients, 41 with Crohn's Disease CD and 28 with ulcerative colitis UC, were finally eligible. JH was detected in 29 CD patients 70.7%, in 10 UC patients 35.7%, and in 17 healthy control subjects 25.4%. Significant difference was detected on JH in CD patients as compared to UC patients and controls . The estimated OR for JH was 7.108 95% CI: 2.98–16.95 in CD and 1.634 95% CI: 0.63–4.22 in UC patients. HMS was detected in 5 12.2% CD and in 1 3.57% UC patients. The OR for HMS in CD was 3.75 95% CI: 0.41–34.007, while 7 17.1% CD patients had overlapping symptoms for both HMS and early spondylarthropathy. Conclusions. JH and the HMS are common in CD patients, thus articular manifestations should be carefully interpreted. This implies an involvement of collagen varieties in the pathogenesis of IBD.





Author: P. Vounotrypidis, E. Efremidou, P. Zezos, M. Pitiakoudis, E. Maltezos, N. Lyratzopoulos, and G. Kouklakis

Source: https://www.hindawi.com/



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