Prevalence of beta-lactam allergy: a retrospective chart review of drug allergy assessment in a predominantly pediatric populationReport as inadecuate




Prevalence of beta-lactam allergy: a retrospective chart review of drug allergy assessment in a predominantly pediatric population - Download this document for free, or read online. Document in PDF available to download.

Allergy, Asthma and Clinical Immunology

, 12:59

First Online: 29 November 2016Received: 03 August 2016Accepted: 31 October 2016

Abstract

BackgroundResearch suggests that 90% of patients labeled beta-lactam allergic are able to tolerate penicillins following further assessment. This study aims to define and describe the frequency of true beta-lactam allergy following allergy patient evaluation in a predominantly pediatric population.

Methods306 primary care patients referred between January 2010 and June 2015 were assessed for a suspected beta-lactam allergy. Patient demographics, history and test results were extracted from electronic medical records. Testing performed was based on specialist recommendation following review of patient history.

Results34% of the study participants had intradermal testing. Oral challenge was given to 96.7% of the sample. 96% of patients with a prior history of beta-lactam allergy were advised that they could re-introduce beta-lactam antibiotics following evaluation.

ConclusionsAmong patients with a documented beta-lactam allergy or a recent history of a reaction there is a low rate of ‘true’ beta-lactam allergy. Consistent evaluation of beta-lactam antibiotic allergies can reduce rates of broad spectrum antibiotic prescribing, among other harmful consequences.

KeywordsAnaphylaxis Beta-lactam allergy Drug allergy, adverse drug reaction AbbreviationsAAAAIAmerican Academy of Allergy Asthma and Immunology

ADRadverse drug reaction

SJSStevens Johnson Syndrome

Download fulltext PDF



Author: Elissa M. Abrams - Andrew Wakeman - Tom V. Gerstner - Richard J. Warrington - Alexander G. Singer

Source: https://link.springer.com/article/10.1186/s13223-016-0165-6



DOWNLOAD PDF




Related documents