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Sleep and Biological Rhythms

, Volume 14, Issue 4, pp 321–328

First Online: 31 May 2016Received: 05 March 2016Accepted: 02 May 2016

Abstract

Epidemiological studies have shown that chronic sleep disturbances resulted in metabolic disorders. The purpose of this study was to assess the relationship between chronic sleep deprivation CSD and the glucose homeostasis in rats. Twenty-four rats were randomly divided into CSD group and control CON group. The CSD rats were intervened by a modified multiple platform method MMPM to establish an animal model of chronic sleep disturbances. After 3-month intervention, all rats were subjected to an intraperitoneal glucose tolerance test IPGTT and an insulin tolerance test ITT, and the body weight, aspartate aminotransferase AST, alanine aminotransferase ALT, creatinine, lipid profile group, and homeostasis model assessment-IR HOMA-IR were measured. Both the CSD and CON groups had an attenuation of weight gain after 3-month intervention. The plasma glucose level of CSD group was higher than that of the CON group during the IPGTT P < 0.01. The CSD rats showed a marked increase in HOMA-IR and ITT compared with the CON group P < 0.01. There were no significant differences of AST, ALT, creatinine, and most lipid parameters between the CSD and CON groups P > 0.05. The CSD has a marked effect on glucose homeostasis, comprising glucose intolerance and insulin resistance.

KeywordsChronic sleep deprivation Glucose intolerance Insulin resistance Body weight X. Xu and L. Wang contributed equally to this work and should be considered co-first authors.

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Author: Xiaowen Xu - Liang Wang - Yan Zhang - Tianjiao Su - Liying Chen - Yan Zhang - Weifeng Ma - Yuanyuan Xie - Tiantian Wang -

Source: https://link.springer.com/article/10.1007/s41105-016-0061-y



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