A High-Fat Diet Enriched with Low Omega-6 to Omega-3 Fatty Acid Ratio Reduced Fat Cellularity and Plasma Leptin Concentration in Sprague-Dawley RatsReport as inadecuate




A High-Fat Diet Enriched with Low Omega-6 to Omega-3 Fatty Acid Ratio Reduced Fat Cellularity and Plasma Leptin Concentration in Sprague-Dawley Rats - Download this document for free, or read online. Document in PDF available to download.

The Scientific World JournalVolume 2013 2013, Article ID 757593, 7 pages

Research Article

Department of Veterinary Preclinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia UPM, 43400 Serdang, Selangor, Malaysia

Institute of Tropical Agriculture, Universiti Putra Malaysia UPM, 43400 Serdang, Selangor, Malaysia

Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia UPM, 43400 Serdang, Selangor, Malaysia

Received 14 August 2013; Accepted 8 September 2013

Academic Editors: E. L. Hooghe-Peters and N. Sugimoto

Copyright © 2013 A. W. Tekeleselassie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study was aimed to investigate the effects of dietary fatty acids on the accretion pattern of major fat pads, inguinal fat cellularity, and their relation with plasma leptin concentration. Forty Sprague-Dawley rats were randomly assigned into four groups and received the following diets for 22 weeks: 1 standard rat chow diet CTRL, 2 CTRL + 10% w-w butter HFAR, 3 CTRL + 3.33% w-w menhaden fish oil + 6.67% w-w soybean oil MFAR, and 4 CTRL + 6.67% w-w menhaden fish oil + 3.33% w-w soybean oil LFAR. Inguinal fat cellularity and plasma leptin concentration were measured in this study. Results for inguinal fat cellularity showed that the mean adipocyte number for the MFAR 9.2   10

 ± 3.6 and LFAR 8.5   10

 ± 5.1 groups was significantly higher than the rest, while the mean adipocyte diameter of HFAR group was larger 46.2 ± 2.8 than the rest. The plasma leptin concentration in the HFAR group was higher 3.22 ± 0.32 ng-mL, than the other groups. The higher inguinal fat cellularity clearly indicated the ability of the polyunsaturated fatty acids PUFA and butter supplemented diets to induce hyperplasia and hypertrophy of fat cells, respectively, which caused adipocyte remodeling due to hyperleptinemia.





Author: A. W. Tekeleselassie, Y. M. Goh, M. A. Rajion, M. Motshakeri, and M. Ebrahimi

Source: https://www.hindawi.com/



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