Design and Synthesis of Two Oxazine Derivatives Using Several StrategiesReport as inadecuate




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Journal of Chemistry - Volume 2014 2014, Article ID 757953, 9 pages -

Research Article

Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Avenida Agustín Melgar s-n, Col Buenavista, 24039 San Francisco de Campeche, CAM, Mexico

Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional, Prol, Carpio y Plan de Ayala s-n, Col Santo Tomas, 11340 Mexico, DF, Mexico

Facultad de Nutrición, Universidad Veracruzana, Médicos y Odontólogos s-n, 91010 Xalapa, VER, Mexico

Faculty of Medicine, University Autonomous of Campeche, Avenida Patricio Trueba de Regil s-n, Col Lindavista, 24090 San Francisco de Campeche, CAM, Mexico

Received 22 October 2013; Accepted 12 December 2013; Published 23 January 2014

Academic Editor: Tanaji Talele

Copyright © 2014 Figueroa-Valverde Lauro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Several oxazine derivatives have been synthesized; nevertheless, expensive reagents and special conditions are required. Therefore, in this study, two oxazine derivatives 2-chloro-3-{{2-3-chloro-2-oxo-cyclobutyl-2,3-dimethoxy-9,10-dihydrostrychnid-10-yl-amino-ethyl}-1,5-dimethyl-4-1H-naphtho1,2-e1,3-oxazin-2-yl-2-phenyl-2,3-dihydro-1H-pyrazol-3-yl-amino}-cyclobutanone and 2-chloro-3-{{2-3-chloro-2-oxo-cyclobutyl-1,7,7-trimethyl-bicyclo2.2.1hept-2-yl-amino-ethyl}-1,5-dimethyl-4-1H-naphtho1,2-e1,3oxazin-2-yl-2-phenyl-2,3-dihydro-1H-pyrazol-3-yl-amino}-cyclobutanone were synthesized using several strategies. The structure of compounds obtained was confirmed by elemental analysis, spectroscopy, and spectrometry data. In conclusion, the methods used offer some advantages such as good yields, simple procedure, low cost, and ease of workup.





Author: Figueroa-Valverde Lauro, Díaz-Cedillo Francisco, Rosas-Nexticapa Marcela, García-Cervera Elodia, Pool-Gómez Eduardo, Lópe

Source: https://www.hindawi.com/



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