Damage of urinary-respiratory system and survival rate is affected by gender in eae model of lewis rat Report as inadecuate




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Cyrus Jalili ; Shahram Parvaneh ; Shahram Mir-Aghaee ; Nafiseh Pakravan ;Acta Scientiae Veterinariae 2015, 43

Author: Ameneh Ghaffarinia

Source: http://www.redalyc.org/articulo.oa?id=289039763013


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Acta Scientiae Veterinariae ISSN: 1678-0345 ActaSciVet@ufrgs.br Universidade Federal do Rio Grande do Sul Brasil Ghaffarinia, Ameneh; Jalili, Cyrus; Parvaneh, Shahram; Mir-Aghaee, Shahram; Pakravan, Nafiseh Damage of Urinary-Respiratory System and Survival Rate is Affected by Gender in EAE Model of Lewis Rat Acta Scientiae Veterinariae, vol.
43, 2015, pp.
1-9 Universidade Federal do Rio Grande do Sul Porto Alegre, Brasil Available in: http:--www.redalyc.org-articulo.oa?id=289039763013 How to cite Complete issue More information about this article Journals homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative Acta Scientiae Veterinariae, 2015.
43: 1269. RESEARCH ARTICLE Pub.
1269 ISSN 1679-9216 Damage of Urinary-Respiratory System and Survival Rate is Affected by Gender in EAE Model of Lewis Rat Ameneh Ghaffarinia1, Cyrus Jalili2, Shahram Parvaneh1, Shahram Mir-Aghaee1 & Nafiseh Pakravan3 ABSTRACT Background: Multiple sclerosis (MS) is a demyelinating chronic inflammatory disease of the central nervous system. Experimental autoimmune encephalomyelitis (EAE) is a widely used model for MS based on autoimmune and histopathological similarities.
Women are more susceptible to multiple sclerosis than men.
This susceptibility has been attributed to sex hormones, sex-linked gene, and more robust immune responses in females.
The aim of this study was to compare survival rate and severity of disease in terms of clinic-pathological signs including nasal bleeding, urinary incontinence and bleeding from urinary tract rate between males and females affected by EAE. Materials, Methods & Results: Lewis rats aged 7-8 weeks were immunized subcutaneously with a homogenate of guinea pig spinal cord and complete Freund’s adjuvant (CFA).
Each rat received 50 μg guinea pig spinal cord and 400 μg Mycobacterium tubercu...





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