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The Scientific World Journal - Volume 2014 2014, Article ID 536161, 7 pages -

Clinical Study

St Paul’s Eye Unit, Royal Liverpool University Hospital, Liverpool L7 8XP, UK

Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L7 8XP, UK

Received 22 July 2014; Accepted 25 August 2014; Published 14 October 2014

Academic Editor: Imre Lengyel

Copyright © 2014 Savitha Madhusudhan and Nicholas Beare. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. The aim of our study was to investigate if peripheral retinal ischaemia contributed to the pathogenesis of neovascular AMD NvAMD, using wide-field fluorescein angiography WFFA. Methods. This prospective study included 30 consecutive patients with newly diagnosed NvAMD in the index eye. Wide-field colour fundus images and fluorescein angiograms were obtained using P200C optomap FA and analysed using a grid with three concentric circles of 50°, 100°, and 200° centred on the fovea to define zones Z1, Z2, and Z3. Results. Areas of peripheral retinal nonperfusion were seen in 2 7% eyes, peripheral vascular leakage in 5 17% eyes, and diffuse dye leakage close to the ora in 5 17% eyes. A total of one-third of the study eyes showed changes on WFFA in Z2 and Z3. On comparing index eyes to nonindex eyes in these patients, the presence of NvAMD was associated with peripheral FA changes , Fisher’s test. Conclusion. Frank peripheral retinal non-perfusion does not appear to be associated with NvAMD. In some patients with active NvAMD there is degradation of the peripheral blood-retina barrier. Smoking was also found to be associated with the above-mentioned abnormalities.

Author: Savitha Madhusudhan and Nicholas Beare

Source: https://www.hindawi.com/


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