Comparative Genomic Hybridization Selection of Blastocysts for Repeated Implantation Failure Treatment: A Pilot StudyReport as inadecuate




Comparative Genomic Hybridization Selection of Blastocysts for Repeated Implantation Failure Treatment: A Pilot Study - Download this document for free, or read online. Document in PDF available to download.

BioMed Research International - Volume 2014 2014, Article ID 457913, 10 pages -

Clinical Study

Center for Reproductive Medicine, European Hospital, Via Portuense 700, 00149 Rome, Italy

GENOMA, Molecular Genetics Laboratory, Via Castel Giubileo 11, 00138 Rome, Italy

Molecular Assisted Reproduction and Genetics MAR&Gen Clinic, Camino de Ronda 2, Bajo, 180 06 Granada, Spain

Received 8 January 2014; Accepted 10 February 2014; Published 23 March 2014

Academic Editor: Irma Virant-Klun

Copyright © 2014 Ermanno Greco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this study is to determine if the use of preimplantation genetic screening PGS by array comparative genomic hybridization array CGH and transfer of a single euploid blastocyst in patients with repeated implantation failure RIF can improve clinical results. Three patient groups are compared: 43 couples with RIF for whom embryos were selected by array CGH group RIF-PGS, 33 couples with the same history for whom array CGH was not performed group RIF NO PGS, and 45 good prognosis infertile couples with array CGH selected embryos group NO RIF PGS. A single euploid blastocyst was transferred in groups RIF-PGS and NO RIF PGS. Array CGH was not performed in group RIF NO PGS in which 1-2 blastocysts were transferred. One monoembryonic sac with heartbeat was found in 28 patients of group RIF PGS and 31 patients of group NO RIF PGS showing similar clinical pregnancy and implantation rates 68.3% and 70.5%, resp

In contrast, an embryonic sac with heartbeat was only detected in 7 21.2% patients of group RIF NO PGS. In conclusion, PGS by array CGH with single euploid blastocyst transfer appears to be a successful strategy for patients with multiple failed IVF attempts.





Author: Ermanno Greco, Sara Bono, Alessandra Ruberti, Anna Maria Lobascio, Pierfrancesco Greco, Anil Biricik, Letizia Spizzichino, 

Source: https://www.hindawi.com/



DOWNLOAD PDF




Related documents