Development, Characterization, and In Vitro Evaluation of Tamoxifen MicroemulsionsReport as inadecuate




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Journal of Drug DeliveryVolume 2012 2012, Article ID 236713, 11 pages

Research Article

Department of Pharmaceutical Technology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina

Institute of Biochemistry and Biophysics, IQUIFIB, National Science Research Council CONICET, Junín 956, 1113 Buenos Aires, Argentina

Received 31 August 2011; Accepted 2 October 2011

Academic Editor: Rassoul Dinarvand

Copyright © 2012 E. Monteagudo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Microemulsions MEs were designed by an innovative rational development, characterized, and used to load up to 20 mM of Tamoxifen citrate TMX. They were made with acceptable and well-characterized excipients for all the routes of administration. Some of their properties, such as nanometric mean size and long stability shelf life, make them interesting drug delivery systems. The results obtained after the in vitro inhibition of estradiol-induced proliferation in MCF-7 breast cancer cells demonstrated a significant effect in cell growth. A decreasing of at least 90% in viable cells was shown after the incubation with MEs containing 20 mM of TMX. Besides, two compositions which loaded 10 mM of drug showed a cytotoxic effect higher than 70%. These results encourage the evaluation of alternative protocols for this drug administration, not only for estrogen receptor ER positive tumors, but also for ER negative.





Author: E. Monteagudo, Y. Gándola, L. González, C. Bregni, and A. M. Carlucci

Source: https://www.hindawi.com/



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