Clinical Features and Drug Characteristics of Patients with Generalized Fixed Drug Eruption in the West of Iran 2005–2014Report as inadecuate




Clinical Features and Drug Characteristics of Patients with Generalized Fixed Drug Eruption in the West of Iran 2005–2014 - Download this document for free, or read online. Document in PDF available to download.

Dermatology Research and Practice - Volume 2015 2015, Article ID 236703, 4 pages -

Research Article

Dermatology Department, Imam Reza Hospital, Kermanshah University of Medical Sciences KUMS, Kermanshah 6714415333, Iran

Health School, Family Health Research Center of Kermanshah University of Medical Sciences KUMS, Kermanshah 6714415333, Iran

Department of Pharmaceutics, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran

Kermanshah University of Medical Sciences KUMS, Kermanshah 6714415333, Iran

Received 30 September 2015; Accepted 1 December 2015

Academic Editor: Craig G. Burkhart

Copyright © 2015 Hossein Kavoussi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Generalized fixed drug eruption is a specific variant of fixed drug eruption with multifocal lesions. Diagnosis of this drug reaction is straightforward, but occasionally recognition of the causative drug is not possible. This study was aimed at evaluating the clinical features and culprit drugs in generalized fixed drug eruptions in the west of Iran. Method. This cross-sectional study was carried out on 30 patients with criteria of generalized fixed drug eruption over 9 years. Demographic, clinical, and drug intake information were collected. Results. Out of 30 patients 17 females and 13 males with the mean age of years, 28 93.3% and 2 6.7% cases had plaque and bullous clinical presentation, respectively. Upper limbs were the most common 90% site of involvement. The antibiotic group, especially cotrimoxazole 26.1%, was reported to be the most common offending drug, but the causative drug was not determined in 7 23.3% patients. Conclusion. Many cases of generalized fixed drug eruption firstly presented as limited lesions and led to generalized lesion due to repeated intake of the causative drug. No causative drug was found in some patients, which might be associated with concurrent intake of several drugs, multiple FDE, and peculiarity of the patch test.





Author: Hossein Kavoussi, Mansour Rezaei, Katayoun Derakhshandeh, Alireza Moradi, Ali Ebrahimi, Harif Rashidian, and Reza Kavoussi

Source: https://www.hindawi.com/



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