PGC-1α Induction in Pulmonary Arterial HypertensionReport as inadecuate




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Oxidative Medicine and Cellular LongevityVolume 2012 2012, Article ID 236572, 8 pages

Research Article

Department of Molecular Medicine, Research Foundation of the University General Hospital of Valencia, 46014 Valencia, Spain

Centro de Investigación Biomédica en Red CIBER de Enfermedades Respiratorias, 46014 Valencia, Spain

Department of Pharmacology, University of Valencia, 46010 Valencia, Spain

Division of Pneumology, University General Hospital of Valencia, 46014 Valencia, Spain

Division of Pneumology, University General Hospital of La Fé, 46026 Valencia, Spain

Division of Pneumology, University General Hospital of Alicante, 03010 Alicante, Spain

Received 4 May 2012; Revised 13 June 2012; Accepted 10 July 2012

Academic Editor: Remi Mounier

Copyright © 2012 Manuel Mata et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Idiopathic Pulmonary arterial hypertension IPAH is characterized by the obstructive remodelling of pulmonary arteries, and a progressive elevation in pulmonary arterial pressure PAP with subsequent right-sided heart failure and dead. Hypoxia induces the expression of peroxisome proliferator activated receptor γ coactivator-1α PGC-1α which regulates oxidative metabolism and mitochondrial biogenesis. We have analysed the expression of PGC-1α, cytochrome C CYTC, superoxide dismutase SOD, the total antioxidant status TAS and the activity of glutathione peroxidase GPX in blood samples of IPAH patients. Expression of PGC-1α was detected in IPAH patients but not in healthy volunteers. The mRNA levels of SOD were lower in IPAH patients compared to controls 3.93 ± 0.89 fold change. TAS and GPX activity were lower too in patients compared to healthy donors, 0.13 ± 0.027 versus 0.484 ± 0.048 mM and 56.034 ± 10.37 versus 165.46 ± 11.38 nmol-min-mL, resp

We found a negative correlation between expression levels of PGC-1α and age, PAP and PVR, as well as a positive correlation with CI, PaO2, mRNA levels of CYTC and SOD, TAS and GPX activity. These results taken together are indicative of the possible role of PGC-1α as a potential biomarker of the progression of IPAH.





Author: Manuel Mata, Irene Sarrion, Lara Milian, Gustavo Juan, Mercedes Ramon, Dolores Naufal, Juan Gil, F. Ridocci, O. Fabregat-A

Source: https://www.hindawi.com/



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