Dietary Supplementation with Omega-3-PUFA-Rich Fish Oil Reduces Signs of Food Allergy in Ovalbumin-Sensitized MiceReport as inadecuate




Dietary Supplementation with Omega-3-PUFA-Rich Fish Oil Reduces Signs of Food Allergy in Ovalbumin-Sensitized Mice - Download this document for free, or read online. Document in PDF available to download.

Clinical and Developmental ImmunologyVolume 2012 2012, Article ID 236564, 9 pages

Research Article

Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil

Laboratório Imunofarmacologia, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil

Departamento de Enfermagem Básica, Escola de Enfermagem, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil

Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil

Received 15 May 2011; Revised 18 August 2011; Accepted 7 September 2011

Academic Editor: Donna-Marie McCafferty

Copyright © 2012 Olívia Gonçalves de Matos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We investigated the effect of dietary supplementation with n-3 PUFA fish oil source in an experimental model of food allergy. Mice were sensitized allergic group or not nonallergic group with OVA and were fed with OVA diet to induce allergy signals. Mice were fed with regular diet in which 7% of lipid content was provided by soybean 5% of n-3 PUFA or fish 25% of n-3 PUFA oil. Allergic group mice had increased serum levels of antiovalbumin IgE and IgG1 and changes in small intestine, characterized by an increased edema, number of rolling leukocytes in microcirculation, eosinophil infiltration, mucus production, and Paneth cell degranulation, in comparison to non-allergic group. All these inflammatory parameters were reduced in mice fed high-n-3-PUFA diet. Our data together suggest that diet supplementation with n-3 PUFA from fish oil may consist of a valid adjuvant in food allergy treatment.





Author: Olívia Gonçalves de Matos, Sylvia Stella Amaral, Pedro Elias Marques Pereira da Silva, Denise Alves Perez, Débora Moreira A

Source: https://www.hindawi.com/



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