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Journal of Nanomaterials - Volume 2017 2017, Article ID 2539520, 6 pages -

Research Article

Materials Science and Nanotechnology Program and Department of Physics, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand

Nanotec-KKU Center of Excellence on Advanced Nanomaterials for Energy Production and Storage, Khon Kaen 40002, Thailand

Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand

Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand

Department of Chemistry and Applied Analytical Chemistry Research Unit, Faculty of Science, King Mongkut’s Institute of Technology Ladkrabang, Bangkok 10520, Thailand

Correspondence should be addressed to Apiwat Chompoosor and Saowapak Teerasong

Received 16 February 2017; Revised 1 May 2017; Accepted 28 May 2017; Published 28 June 2017

Academic Editor: Paulo Cesar Morais

Copyright © 2017 Saowalak Somjid et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The results of releasing a drug in a burst are unpredictable and one of the inherent drawbacks of using nanocarriers. Here, photoresponsive cationic gold nanoparticles to stabilize diacetylenic nanocapsules enabling photoregulated release of payloads are reported. The fabrication of these nanocapsules relied on an electrostatic interaction of a negatively charged diacetylenic core and a positively charged gold nanoparticle shell. Gold nanoparticles with photoresponsive ligands on their surfaces act as both hydrophobic core stabilizers and gatekeepers of the nanocapsules, while their polydiacetylene cores serve as hydrophobic drug carriers that can be tuned using UV irradiation. The morphology of nanocapsules was analyzed using TEM and dynamic light scattering. The resultant nanocapsules had a spherical shape with an average diameter of 152.9 ± 6.7 nm. Upon UV irradiation, the nanocapsules lost their integrity and an encapsulated model compound was released through diffusion. The release of a hydrophobic molecule was irradiation time dependent and thereby controllable. This light-triggered release provides an alternative strategy for controlled drug delivery.

Author: Saowalak Somjid, Apiwat Chompoosor, Somdej Kanokmedhakul, and Saowapak Teerasong



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