Quality, Stability, and Safety Data of Packed Red Cells and Plasma Processed by Gravity Separation Using a New Fully Integrated Hollow-Fibre Filter DeviceReport as inadecuate




Quality, Stability, and Safety Data of Packed Red Cells and Plasma Processed by Gravity Separation Using a New Fully Integrated Hollow-Fibre Filter Device - Download this document for free, or read online. Document in PDF available to download.

Advances in HematologyVolume 2010 2010, Article ID 175234, 6 pages

Research Article

University Children's Hospital, Gerhart-Hauptmann- Strasse 35, 39108 Magdeburg, Germany

Department of Transfusion Medicine, Marienkrankenhaus, Hamburg, Germany

Institute for Clinical Transfusion Medicine, Städtisches Klinikum, Braunschweig gGmhG, Germany

Received 8 July 2009; Revised 19 November 2009; Accepted 25 November 2009

Academic Editor: Neil Blumberg

Copyright © 2009 T. Brune et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. We developed a completely closed system based on gravity separation without centrifugation steps for separation of whole blood. With this new system we compared quality and stability of the processed blood components PRC and plasma with respect to classical preparation. Furthermore the cost-effectiveness of this hollow fibre system was evaluated. Study Design and Methods. Whole blood collections of 15 regular blood donors were used for component preparation using the U shaped hollow fibre filter device. Results were compared to 15 whole blood preparations using centrifugation. The following parameters were evaluated: total hemoglobin, leukocyte counts, the serum concentration of total protein, lactate dehydrogenase LDH and potassium. Furthermore ATIII, vWF and F VIII were analyzed at different timepoints. Results. packed red cells: the data directly after separation and after 42 days of storage are in line with the guidelines of the council of Europe. Plasma. all plasma quality data are in line with the guidelines of the council of Europe for quality assurance of plasma, except for a low protein amount factor 0.75. Conclusion. Separation of whole blood on a clinical scale in this new closed system is feasible, however the plasma protein content must be optimized.





Author: T. Brune, K. Hannemann-Pohl, K. Nißle, N. Ecker, and H. Garritsen

Source: https://www.hindawi.com/



DOWNLOAD PDF




Related documents