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The Scientific World Journal - Volume 2014 2014, Article ID 898361, 6 pages -

Clinical Study

Cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Department of Biotechnology, Science & Research Branch, Islamic Azad University, Tehran, Iran

Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Neurogenic Inflammation Research Centre, Department of Medical Biotechnology, Mashhad University of Medical Sciences, Mashhad, Iran

Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Department of Plant Breeding, Science & Research Branch, Islamic Azad University, Tehran, Iran

Deputy of Research, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Division of Medical Education, Mayfield House, University of Brighton, Room 342, Brighton BN1 9PH, UK

Biochemistry of Nutrition Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Received 20 August 2013; Accepted 17 November 2013; Published 11 February 2014

Academic Editors: K. Kantartzis and G. P. Shi

Copyright © 2014 Shiva Ganjali et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Obesity is a disorder often accompanied by a heightened state of systemic inflammation and immunoactivation. The present randomized crossover trial aimed to investigate the efficacy of curcumin, a bioactive polyphenol with established anti-inflammatory and immunomodulatory effects, on the serum levels of a panel of cytokines and mediators in obese individuals. Methods. Thirty obese individuals were randomized to receive curcumin at a daily dose of 1 g or a matched placebo for 4 weeks. Following a 2-week wash-out period, each group was assigned to the alternate treatment regimen for another 4 weeks. Serum samples were collected at the start and end of each study period. Serum levels of IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, VEGF, IFNγ, EGF, MCP-1, and TNFα were measured using a multiplex Biochip Array Technology based method. Results. Mean serum IL-1β , IL-4 , and VEGF were found to be significantly reduced by curcumin therapy. In contrast, no significant difference was observed in the concentrations of IL-2, IL-6, IL-8, IL-10, IFNγ, EGF, and MCP-1. Conclusions. The findings of the present trial suggested that curcumin may exert immunomodulatory effects via altering the circulating concentrations of IL-1β, IL-4, and VEGF.





Author: Shiva Ganjali, Amirhossein Sahebkar, Elahe Mahdipour, Khadijeh Jamialahmadi, Sepideh Torabi, Saeed Akhlaghi, Gordon Ferns, 

Source: https://www.hindawi.com/



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