Clinical Studies of Nonpharmacological Methods to Minimize Salivary Gland Damage after Radioiodine Therapy of Differentiated Thyroid Carcinoma: Systematic ReviewReport as inadecuate




Clinical Studies of Nonpharmacological Methods to Minimize Salivary Gland Damage after Radioiodine Therapy of Differentiated Thyroid Carcinoma: Systematic Review - Download this document for free, or read online. Document in PDF available to download.

Evidence-Based Complementary and Alternative Medicine - Volume 2016 2016, Article ID 6795076, 11 pages -

Review Article

Department of Nursing, School of Health Sciences, Cyprus University of Technology, 3036 Limassol, Cyprus

Thyroid Cancer Unit, Nuclear Medicine Department, Bank of Cyprus Oncology Center, 2006 Nicosia, Cyprus

University of Turku, 20014 Turku, Finland

Received 24 March 2016; Revised 23 May 2016; Accepted 5 June 2016

Academic Editor: Deborah A. Kennedy

Copyright © 2016 Andri Christou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To systematically review clinical studies examining the effectiveness of nonpharmacological methods to prevent-minimize salivary gland damage due to radioiodine treatment of differentiated thyroid carcinoma DTC. Methods. Reports on relevant trials were identified by searching the PubMed, CINHAL, Cochrane, and Scopus electronic databases covering the period 01-2000–10-2015. Inclusion-exclusion criteria were prespecified. Search yielded eight studies that were reviewed by four of the present authors. Results. Nonpharmacological methods used in trials may reduce salivary gland damage induced by radioiodine. Sialogogues such as lemon candy, vitamin E, lemon juice, and lemon slice reduced such damage significantly , , , and , resp

Parotid gland massage also reduced the salivary damage significantly . Additionally, vitamin C had some limited effect , whereas no effect was present in the case of chewing gum . Conclusion. The review showed that, among nonpharmacological interventions, sialogogues and parotid gland massage had the greatest impact on reducing salivary damage induced by radioiodine therapy of DTC. However, the studies retrieved were limited in number, sample size, strength of evidence, and generalizability. More randomized controlled trials of these methods with multicenter scope and larger sample sizes will provide more systematic and reliable results allowing more definitive conclusions.





Author: Andri Christou, Evridiki Papastavrou, Anastasios Merkouris, Savvas Frangos, Panayiota Tamana, and Andreas Charalambous

Source: https://www.hindawi.com/



DOWNLOAD PDF




Related documents