Successful Utilization of High-Flux Hemodialysis for Treatment of Vancomycin Toxicity in a ChildReport as inadecuate




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Case Reports in PediatricsVolume 2011 2011, Article ID 678724, 4 pages

Case Report

Pediatric Intensive Care Unit, Section of Critical Care Medicine, Children-s Hospital Colorado and University of Colorado at Denver, 13123 East 17th Avenue, Mail Stop 8414, Aurora, CO 80045, USA

Pediatric Intensive Care Unit, Department of Pharmacy, Center for Pediatric Medicine, Children-s Hospital Colorado and University of Colorado Denver School of Pharmacy, 13123 East 17th Avenue, Campus Box 375, Aurora, CO 80045, USA

Department of Nephrology, University of Colorado at Denver and Children-s Hospital Colorado, 13123 East 16th Avenue, Campus Box B328, Aurora, CO 80045, USA

Pediatric Intensive Care Unit, Section of Critical Care Medicine, University of Colorado at Denver and Children-s Hospital Colorado, 13123 East 17th Avenue, Campus Box B530, Aurora, CO 80045, USA

Received 2 November 2011; Accepted 28 December 2011

Academic Editors: N. Arslan and D. Fischer

Copyright © 2011 Timothy Stidham et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Vancomycin is routinely used for empiric antibiotic therapy in children. Higher-serum-concentration targets for serious infections are now being recommended. This recommendation may result in aggressive dosing with increased potential for toxicity. We report a case of a pediatric patient who developed vancomycin toxicity and associated oliguric renal failure who was treated effectively with high-flux hemodialysis for vancomycin toxicity, clearing serum concentrations of vancomycin by over 75% in only 6 hours 213.2 mcg-mL to 51.8 mcg-mL with subsequent return to baseline renal function and without adverse sequelae. While not historically considered a viable option for drug removal in cases of toxicity, new high-flux hemodialysis techniques can remove significant percentages of vancomycin in short periods of time.





Author: Timothy Stidham, Pamela D. Reiter, Douglas M. Ford, Gary M. Lum, and Joseph Albietz

Source: https://www.hindawi.com/



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