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Critical Care

, 12:R67

First Online: 13 May 2008Received: 20 February 2008Revised: 16 April 2008Accepted: 13 May 2008

Abstract

IntroductionThe optic nerve sheath diameter ONSD may be increased in brain-injured patients, especially children, with intracranial hypertension. We investigated whether measurements of ONSD correlated with simultaneous noninvasive and invasive measurements of the intracranial pressure ICP in brain-injured adults.

MethodsSeventy-six critical care patients 58 males; 47 ± 18 years old were included in the study. Fifty patients suffered from brain injury, whereas 26 had no intracranial pathology and served as control individuals. Initially, brain-injured patients were evaluated clinically Glasgow Coma Scale and using a semiquantitative I to VI neuroimaging scale Marshall Scale. Thereafter, the patients were divided into those with moderate Marshall Scale = I and Glasgow Coma Scale > 8 n = 18 and severe Marshall Scale = II to VI and Glasgow Coma Scale ≤8 n = 32 brain injury. All patients underwent noninvasive measurement of the ICP estimated ICP by transcranial Doppler sonography, and synchronous ONSD measurements by optic nerve sonography. Finally, invasive ICP measurement using an intraparenchymal catheter was performed in patients with severe brain injury.

ResultsONSD and estimated ICP were both significantly increased 6.1 ± 0.7 mm and 26.2 ± 8.7 mmHg, respectively; P < 0.0001 in patients with severe brain injury as compared with patients with moderate brain injury 4.2 ± 1.2 mm and 12.0 ± 3.6 mmHg and compared with control individuals 3.6 ± 0.6 mm and 10.3 ± 3.1 mmHg. Furthermore, in patients with severe brain injury the ONSD measurements were strongly correlated with estimated ICP values r = 0.80, P < 0.0001 as well as with the neuroimaging scale results r = 0.82, P < 0.001. In the patients with severe brain injury, ONSD measurements correlated with invasive ICP values r = 0.68, P = 0.002. The best cut-off value of ONSD for predicting elevated ICP was 5.7 mm sensitivity = 74.1% and specificity = 100%.

ConclusionONSD measurements correlate with noninvasive and invasive measurements of the ICP, and with head computed tomography scan findings in brain-injured adults. Hence, optic nerve sonography may serve as an additional diagnostic tool that could alert clinicians to the presence of elevated ICP, whenever invasive ICP evaluation is contraindicated and-or is not available. This trial is International Standard Randomised Controlled Trial Number registered ISRCTN 91941687.

AbbreviationsCIconfidence interval

CSFcerebrospinal fluid

CTcomputed tomography

FVdend-diastolic velocity

FVmmean velocity

eICPestimated intracranial pressure

GCSGlasgow Coma Scale

ISUintensive care unit

ICPintracranial pressure

ONSDoptic nerve sheath diameter

ROCreceiver operating characteristic

TCDtranscranial Doppler sonography.

Electronic supplementary materialThe online version of this article doi:10.1186-cc6897 contains supplementary material, which is available to authorized users.

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Author: Theodoros Soldatos - Dimitrios Karakitsos - Katerina Chatzimichail - Matilda Papathanasiou - Athanasios Gouliamos - Andreas 

Source: https://link.springer.com/



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