Comparison of Fibroblast and Vascular Cell Adhesion to Nano-Structured Polylactic-co-glycolic acid FilmsReport as inadecuate




Comparison of Fibroblast and Vascular Cell Adhesion to Nano-Structured Polylactic-co-glycolic acid Films - Download this document for free, or read online. Document in PDF available to download.

Applied Bionics and Biomechanics - Volume 2 2005, Issue 1, Pages 1-7

Department of Biomedical Engineering, Purdue University, 500 Central Drive, West Lafayette, IN, USA



Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The success of small diameter vascular grafts may be attributed to the ability to accurately mimic the nano-structured topography of extra-cellular matrix components of natural vascular tissue. Using this knowledge, the goal of the present study was to develop synthetic biomaterials that promote vascular cell adhesion and growth, while subsequently limiting fibrous tissue formation. For this purpose, polylactic-co-glycolic acid PLGA with increased nanometer surface roughness was created by treating the surfaces of conventional PLGA with NaOH. Cell experiments on these surfaces indicated that nano-structured PLGA enhanced vascular smooth muscle cell adhesion and growth, while decreasing endothelial cell and fibroblast adhesion and growth, compared to their conventional counterparts. These favorable results were attributed to the selective adsorption of vitronectin. In combination, results of the present in vitro study provided evidence that nano-structured surface features have the potential to significantly improve the efficacy of small diameter vascular implants.





Author: D. C. Miller, R. J. Vance, A. Thapa, T. J. Webster, and K. M. Haberstroh

Source: https://www.hindawi.com/



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