Correlations of Ezrin Expression with Pathological Characteristics and Prognosis of Osteosarcoma: A Meta-AnalysisReport as inadecuate




Correlations of Ezrin Expression with Pathological Characteristics and Prognosis of Osteosarcoma: A Meta-Analysis - Download this document for free, or read online. Document in PDF available to download.

The Scientific World Journal - Volume 2014 2014, Article ID 837543, 10 pages -

Research Article

3rd Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Harbin 150001, China

4th Department of Orthopedics, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China

Department of Orthopedics, China Japan Union Hospital of Jilin University, Changchun 130033, China

Received 14 May 2014; Revised 20 August 2014; Accepted 20 August 2014; Published 27 November 2014

Academic Editor: Gene P. Siegal

Copyright © 2014 Da-Hang Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We conducted a meta-analysis to comprehensively evaluate the correlations of ezrin expression with pathological characteristics and the prognosis of osteosarcoma. The MEDLINE 1966–2013, the Cochrane Library Database, EMBASE, CINAHL, Web of Science 1945–2013, and the Chinese Biomedical Database were searched without language restrictions. Meta-analyses conducted using STATA software were calculated. Ten studies met the inclusion criteria, including 459 patients with osteosarcoma. Meta-analysis results illustrated that ezrin expression may be closely associated with the recurrence of osteosarcoma or metastasis in osteosarcoma. Our findings also demonstrated that patients with grade III-IV osteosarcoma showed a higher frequency of ezrin expression than those with histological grade I-II osteosarcoma. Furthermore, we found that patients with positive expression of ezrin exhibited a shorter overall survival than those with negative ezrin expression. The results also indicated that positive ezrin expression was strongly correlated with poorer metastasis-free survival. Nevertheless, no significant relationships were observed between ezrin expression and clinical variables age and gender. In the current meta-analysis, our results illustrated significant relationships of ezrin expression with pathological characteristics and prognosis of osteosarcoma. Thus, ezrin expression could be a promising marker in predicting the clinical outcome of patients with osteosarcoma.





Author: Da-Hang Zhao, Jiang Zhu, Wen-Bo Wang, Feng Dong, Qiao Zhang, Hong-Wu Fan, Jing-Zhe Zhang, and Yong-Ming Wang

Source: https://www.hindawi.com/



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