Triple Negative Breast Carcinoma: A Comparative Study between Breast Lesion and Lymph Node Metastases: A Preliminary StudyReport as inadecuate




Triple Negative Breast Carcinoma: A Comparative Study between Breast Lesion and Lymph Node Metastases: A Preliminary Study - Download this document for free, or read online. Document in PDF available to download.

ISRN PathologyVolume 2011 2011, Article ID 598131, 6 pages

Research Article

Servei de Patologia, Hospital Universitari Sant Joan de Reus, Institut d-Investigació Sanitaria Pere Virgili IISPV, Universitat Rovira i Virgili, Reus, 43206 Tarragona, Spain

Epidemiología, Estadística i Bioinformàtica, Institut d-Investigació Sanitaria Pere Virgili IISPV, Universitat Rovira i Virgili, Reus, 43007 Tarragona, Spain

Received 18 May 2011; Accepted 14 June 2011

Academic Editors: A. Gocht, A. Pagani, T. Shien, and A. Stringer

Copyright © 2011 David Parada et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aims and Background. Triple negative breast carcinoma is a genetic and molecular subtype of breast carcinoma with poor prognosis. Some immunohistochemistry studies have been proposed to identify BLBC. Most studies consider primary breast carcinoma but not metastases. Methods. Immunohistochemical characteristics in 11 triple negative breast carcinomas were studied in both primary lesions and lymph node metastases. All cases were reevaluated to estrogen and progesterone receptors and HER2-Neu. An FISH probe for HER2-neu was also performed. Immunohistochemical studies were performed with cytokeratin 5-6, 17, Cam 5.2, p63, EGFR, and Ki-67 in breast carcinoma and lymph node metastases. Results. The age of the patients ranged between 42 and 73 years mean 53, and the mean followup was 68.25 months. A total of 54.55% of the patients were disease-free, and 45.45% died of carcinoma. Axillary lymph nodes maintained triple negative phenotype 11-11. Metastatic tumors showed CAM 5.2 81.83% and EGFR 72.73% expression. Basal marker expression was variable in primary carcinoma and lymph node metastases 63.64%. Conclusions. Triple negative breast carcinomas maintained this immunoprofile at lymph node metastases. Triple negative carcinomas showed variable expression of basal cell markers.





Author: David Parada, Karla Peña, Francesc Riu, and Pilar Hernandez

Source: https://www.hindawi.com/



DOWNLOAD PDF




Related documents