Genetic test to stop smoking GeTSS trial protocol: randomised controlled trial of a genetic test Respiragene and Auckland formula to assess lung cancer riskReport as inadecuate




Genetic test to stop smoking GeTSS trial protocol: randomised controlled trial of a genetic test Respiragene and Auckland formula to assess lung cancer risk - Download this document for free, or read online. Document in PDF available to download.

BMC Pulmonary Medicine

, 14:77

Health behavior, health promotion and society

Abstract

BackgroundA gene-based estimate of lung cancer risk in smokers has been shown to act as a smoking cessation motivator in hospital recruited subjects. The objective of this trial is to determine if this motivator is as effective in subjects recruited from an NHS primary care unit.

Method-DesignSubjects will be recruited by mailings using smoking entries on the GP electronic data-base total practice population = 32,048 to identify smokers who may want to quit. Smoking cessation clinics based on medical centre premises will run for eight weeks. Clinics will be randomised to have the gene-based test for estimation of lung cancer risk or to act as controls groups. The primary endpoint will be smoking cessation at eight weeks and six months. Secondary outcomes will include ranking of the gene-based test with other smoking cessation motivators.

DiscussionThe results will inform as to whether the gene-based test is both effective as motivator and acceptable to subjects recruited from primary care.

Trial registrationRegistered with Clinical Trials.gov, Registration number: NCT01176383.

KeywordsSmoking cessation Genetic test Lung cancer AbbreviationsCONSORTConsolidated statement of reporting trials

COPDChronic obstructive pulmonary disease

DNADeoxyribonucleic acid

NHSNational health service UK

SNPSingle nucleotide polymorphism

SAEStamped addresses envelope.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2466-14-77 contains supplementary material, which is available to authorized users.

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Author: John AA Nichols - Paul Grob - Simon de Lusignan - Wendy Kite - Peter Williams

Source: https://link.springer.com/



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