Conservative fluid therapy in septic shock: an example of targeted therapeutic minimizationReport as inadecuate




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Critical Care

, 18:481

First Online: 29 August 2014

Abstract

Intravenous fluids IVFs represent a basic therapeutic intervention utilized in septic shock. Unfortunately, the optimal method for administering IVFs to maximize patient outcomes is unknown. A meta-analysis of four randomized trials of goal-directed therapy did not demonstrate a significant reduction in mortality odds ratio 0.609; 95% confidence interval 0.363 to 1.020; P = 0.059, whereas 18 trials with historical controls showed a significant increase in survival odds ratio 0.580; 95% confidence interval 0.501 to 0.672; P < 0.0001. Based on these data, clinicians should be aware of the potential for harm due to the excessive administration of IVFs to patients with septic shock.

AbbreviationsCIConfidence interval

CVPCentral venous pressure

GDTGoal-directed therapy

IVFIntravenous fluid

OROdds ratio

ScvO2Superior vena cava oxygen saturation

Electronic supplementary materialThe online version of this article doi:10.1186-s13054-014-0481-5 contains supplementary material, which is available to authorized users.

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Author: Catherine Chen - Marin H Kollef

Source: https://link.springer.com/



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