Serum angiopoietin is associated with lung function in patients with asthma: a retrospective cohort studyReport as inadecuate




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BMC Pulmonary Medicine

, 14:143

Asthma and allergic disorders

Abstract

BackgroundAngiopoietin-1 Ang-1 is an essential mediator of angiogenesis that establishes vascular integrity, and angiopoietin-2 Ang-2 acts as its natural inhibitor. We considered that angiopoietin might be important in bronchial asthma.

MethodsIn total, 35 patients with asthma and 20 healthy subjects were studied.

ResultsThe serum Ang-1 levels were significantly elevated in patients with asthma compared to control subjects 293.9 ± 13.8 pg-mL vs. 248.3 ± 16.2 pg-mL, respectively, p = 0.04. The serum Ang-2 levels were not different between the two groups. The areas under the curve AUC for serum angiopoietins revealed that the serum level of Ang-1 0.68 was more sensitive and specific than the serum Ang-2 level 0.55 for differentiating between patients with asthma and control subjects. The serum Ang-1-Ang-2 ratio was correlated with the FEV1-FVC ratio r = -0.312, p = 0.02, while serum Ang-2 was correlated with body mass index.

ConclusionsOur results indicate that the serum Ang-1 levels were higher in asthma patients compared with healthy subjects. As the Ang-1-Ang-2 ratio was related to lung function, the data suggest that serum angiopoietin is associated with lung function in patients with asthma.

KeywordsAngiogenesis Angiopoietin-1 Angiopoietin-2 Asthma Electronic supplementary materialThe online version of this article doi:10.1186-1471-2466-14-143 contains supplementary material, which is available to authorized users.

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Author: Kuk-Young Moon - PuReun-HaNeul Lee - Sung-Woo Park - Choon-Sik Park - An-Soo Jang

Source: https://link.springer.com/







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