Serum Liver Fibrosis Markers for Predicting the Presence of Gastroesophageal Varices in Liver Cirrhosis: A Retrospective Cross-Sectional StudyReport as inadecuate




Serum Liver Fibrosis Markers for Predicting the Presence of Gastroesophageal Varices in Liver Cirrhosis: A Retrospective Cross-Sectional Study - Download this document for free, or read online. Document in PDF available to download.

Gastroenterology Research and PracticeVolume 2015 2015, Article ID 274534, 6 pages

Research ArticleLiver Cirrhosis Study Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, 83 Wenhua Road, Shenyang 110840, China

Received 23 January 2015; Revised 23 April 2015; Accepted 28 April 2015

Academic Editor: Marcela Kopacova

Copyright © 2015 Xingshun Qi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background and Aims. A retrospective cross-sectional study was conducted to evaluate the role of hyaluronic acid HA, laminin LN, amino-terminal propeptide of type III procollagen PIIINP, and collagen IV CIV in predicting the presence of gastroesophageal varices GEVs in patients with liver cirrhosis. Methods. We enrolled 118 patients with liver cirrhosis who underwent the tests for the four serum liver fibrosis markers and upper gastrointestinal endoscopy at the same admissions. The predictive values of the four serum liver fibrosis markers were evaluated by the areas under the receiving operator characteristics curves AUROCs with 95% confidence intervals CIs. Results. The prevalence of GEVs was 88% 104-118. The AUROCs for HA, LN, PIIINP, and CIV levels in predicting the presence of GEVs were 0.553 95% CI: 0.458 to 0.644, , 0.490 95% CI: 0.397 to 0.584, , 0.622 95% CI: 0.528 to 0.710, , and 0.560 95% CI: 0.466 to 0.652, . The PIIINP level at a cut-off value of 31.25 had a sensitivity of 73.1% and a specificity of 57.1%. Conclusions. The present study did not recommend HA, LN, PIIINP, and CIV levels to evaluate the presence of GEVs in liver cirrhosis.





Author: Xingshun Qi, Hongyu Li, Jiang Chen, Chunlian Xia, Ying Peng, Junna Dai, Yue Hou, Han Deng, Jing Li, and Xiaozhong Guo

Source: https://www.hindawi.com/



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