Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate.Report as inadecuate




Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate. - Download this document for free, or read online. Document in PDF available to download.

* Corresponding author 1 LBMC - Laboratoire de Biochimie Moléculaire et Cellulaire 2 DMEO - Department of Medicine and Experimental Oncology 3 Laboratory of metabolism

Abstract : Humans appear to be refractory to some effects of peroxisome proliferators including alterations in cell proliferation, whereas rodents are susceptible. In this study, differences between the human and rat response to peroxisome proliferators were evaluated using rat and human tumour liver cell lines. Rat 7777 cells were more responsive than human HepG2 cells to ciprofibrate as they exhibited a higher decrease in cell number than HepG2, and underwent apoptosis. Results from these studies reveal a surprising response in tumour cell lines as the typical in vivo response of increased cell proliferation and reduced apoptosis was not observed in rat tumour cell lines at concentrations greater than those used to elicit the former response.





Author: Marie-Claude Clemencet - Giuliana Muzio - Antonella Trombetta - Jeffrey M Peters - Frank J Gonzalez - Rosa A Canuto - Norbert Lat

Source: https://hal.archives-ouvertes.fr/



DOWNLOAD PDF




Related documents