Comprehensive Evidence-Based Assessment and Prioritization of Potential Antidiabetic Medicinal Plants: A Case Study from Canadian Eastern James Bay Cree Traditional MedicineReport as inadecuate




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Evidence-Based Complementary and Alternative MedicineVolume 2012 2012, Article ID 893426, 14 pages

Review Article

Canadian Institutes of Health Research Team in Aboriginal Antidiabetic Medicines, Montreal, QC, Canada H3C 317

Department of Pharmacology, Université de Montréal and Montreal Diabetes Research Center, P.O. Box 6128, Downtown Postal Station, Montreal, QC, Canada H3C 3J7

School of Dietetics and Human Nutrition and Center for Indigenous Peoples’ Nutrition and Environment, McGill University, Sainte-Anne-de-Bellevue, QC, Canada H9X 3V9

Department of Biology, University of Ottawa, Ottawa, ON, Canada K1N 6N5

Department of Cellular and Molecular Medicine, University of Ottawa and Therapeutic Products Directorate, Health Canada, Ottawa, ON, Canada K1A 1B6

Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada K1H 8M5

Plant Biology Research Institute, Université de Montréal and Montreal Botanical Garden, Montreal, QC, Canada H1X 2B2

Cree Nation of Mistissini, Eeyou Istchii, QC, Canada GOW 1CO

The Crees of Waskaganish First Nation, Eeyou Istchii, QC, Canada JON 1RO

Whapmagoostui First Nation, Eeyou Istchii, QC, Canada JOM 1GO

Cree Nation of Nemaska, Nemaska, QC, Canada JLY 3BO

Office of Biotechnology, Genomics, and Population Health, Public Health Agency of Canada, Toronto, ON, Canada M5V 3L7

Received 18 May 2011; Accepted 9 September 2011

Academic Editor: Arndt Büssing

Copyright © 2012 Pierre S. Haddad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Canadian Aboriginals, like others globally, suffer from disproportionately high rates of diabetes. A comprehensive evidence-based approach was therefore developed to study potential antidiabetic medicinal plants stemming from Canadian Aboriginal Traditional Medicine to provide culturally adapted complementary and alternative treatment options. Key elements of pathophysiology of diabetes and of related contemporary drug therapy are presented to highlight relevant cellular and molecular targets for medicinal plants. Potential antidiabetic plants were identified using a novel ethnobotanical method based on a set of diabetes symptoms. The most promising species were screened for primary glucose-lowering and secondary toxicity, drug interactions, complications antidiabetic activity by using a comprehensive platform of in vitro cell-based and cell-free bioassays. The most active species were studied further for their mechanism of action and their active principles identified though bioassay-guided fractionation. Biological activity of key species was confirmed in animal models of diabetes. These in vitro and in vivo findings are the basis for evidence-based prioritization of antidiabetic plants. In parallel, plants were also prioritized by Cree Elders and healers according to their Traditional Medicine paradigm. This case study highlights the convergence of modern science and Traditional Medicine while providing a model that can be adapted to other Aboriginal realities worldwide.





Author: Pierre S. Haddad, Lina Musallam, Louis C. Martineau, Cory Harris, Louis Lavoie, John T. Arnason, Brian Foster, Steffany Ben

Source: https://www.hindawi.com/



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