Elevation of soluble interleukin-2 receptor levels in nasal allergyReport as inadecuate




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Mediators of Inflammation - Volume 4 1995, Issue 1, Pages 39-42

Department of Otorhinolaryngology, Yamanashi Medical University, 1110 Shimokato, Tamaho-cho, Nakakoma-gun, Yamanashi, 409-38, Japan



Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

To investigate soluble IL-2 receptor sIL-2R levels in nasal allergy, the sera and nasal secretions from patients with nasal allergy and from healthy subjects were subjected to a double-epitope enzyme-linked immunosorbent assay. Significant elevation of sIL-2R concentrations in the sera and nasal secretions was observed in the allergy patients n = 26 compared with those of healthy subjects n = 9. IL-2R-positive CD25

cells were observed in the crust formed in an allergic nasal mucosa. The concentration of sIL-2R in the sera correlated neither with the eosinophil count of the peripheral blood count nor with clinical severity. The concentration of sIL-2R in the nasal secretions was significantly higher compared with that in the sera from allergic patients p < 0.01, whereas no significant difference was observed between sIL-2R levels in the sera and nasal sections from normal subjects. These findings indicate that sIL-2R plays an essential role in allergic processes by regulating IL-2R-positive cells recruited into the nasal mucosa.





Author: K. Hisamatsu, T. Ganbo, T. Nakazawa, S. Horiguchi, S. Shimomura, and Y. Murakami

Source: https://www.hindawi.com/



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