Migrating Polyarthritis as a Feature of Occult Malignancy: 2 Case Reports and a Review of the LiteratureReport as inadecuate




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Case Reports in Oncological Medicine - Volume 2015 2015, Article ID 934039, 7 pages -

Case Report

St. Vincent’s University Hospital, Dublin, Ireland

Mater Misericordiae University Hospital, Dublin, Ireland

Received 20 August 2015; Accepted 5 October 2015

Academic Editor: Annekathryn Goodman

Copyright © 2015 Geoffrey Alan Watson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Malignant disease may be associated with a wide variety of musculoskeletal syndromes. Rarely the musculoskeletal system can be indirectly affected by paraneoplastic phenomena, such as carcinomatous polyarthritis CP. The differential diagnosis for CP is broad and is often a diagnosis of exclusion. CP often presents similarly to other forms of inflammatory arthritis, and a detailed history and physical examination can often distinguish CP from other more common causes of polyarticular arthritis. However serological tests such as rheumatoid factor RF and anti-citrullinated peptide anti-CCP antibody positivity, while rare, can be misleading. Clinical awareness and suspicion are paramount in achieving an accurate diagnosis and early detection of an occult neoplasm is critical for prompt management and therapy. We report two cases presenting with this unique clinical phenotype associated with paraneoplastic polyarthropathy and review the literature.





Author: Geoffrey Alan Watson, Lorraine O’Neill, Ruth Law, Geraldine McCarthy, and Douglas Veale

Source: https://www.hindawi.com/



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