Integrated Analysis Identifies Interaction Patterns between Small Molecules and PathwaysReport as inadecuate

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BioMed Research International - Volume 2014 2014, Article ID 931825, 10 pages -

Research Article

Department of Bioinformatics, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 210029, China

Faculty of Health Sciences, University of Macau, Macau

Received 1 March 2014; Revised 13 May 2014; Accepted 22 May 2014; Published 13 July 2014

Academic Editor: Siyuan Zheng

Copyright © 2014 Yan Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Previous studies have indicated that the downstream proteins in a key pathway can be potential drug targets and that the pathway can play an important role in the action of drugs. So pathways could be considered as targets of small molecules. A link map between small molecules and pathways was constructed using gene expression profile, pathways, and gene expression of cancer cell line intervened by small molecules and then we analysed the topological characteristics of the link map. Three link patterns were identified based on different drug discovery implications for breast, liver, and lung cancer. Furthermore, molecules that significantly targeted the same pathways tended to treat the same diseases. These results can provide a valuable reference for identifying drug candidates and targets in molecularly targeted therapy.

Author: Yan Li, Weiguo Li, Xin Chen, Hong Jiang, Jiatong Sun, Huan Chen, and Sali Lv



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