The Role of p53 and MDM2 in Head and Neck CancerReport as inadecuate




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ISRN OtolaryngologyVolume 2011 2011, Article ID 931813, 8 pages

Review Article

Oncology Department, ASO Santa Croce e Carle Cuneo, Via Michele Coppino 21, 12100 Cuneo, Italy

Radiotherapy Department, ASO Santa Croce e Carle Cuneo, Via Michele Coppino 21, 12100 Cuneo, Italy

Oncology Department, Policlinico G Martino, Via Consolare Valeria 1, 98100 Messina, Italy

Received 6 September 2011; Accepted 29 September 2011

Academic Editors: K. Ishikawa and M. Khyatti

Copyright © 2011 N. Denaro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Head and neck cancer is a complex disorder that includes mostly squamous cell carcinomas that can develop in the throat, larynx, nose, sinuses, and mouth. Etiopathogenesis is due to tobacco and alcohol consumption and to infection by human papillomavirus HPV type 16-18. Tumors often develop within preneoplastic fields of genetically altered cells. Most head and neck cancers result from multistep accumulation of genetic alterationsm resulting in clonal outgrowth of transformed cells. These DNA changes are caused by a variety of mechanisms like endogenous mutations and exogenous mutations. Dysregulated molecular pathway includes alterations of critical inhibitor of cyclin CDK complexes, inactivating mutations of p53 gene, and activation of oncogenes and growth factors. This paper attempts to review the role of p53 and MDM2 genetic aberrations and pathways in head and neck cancer.





Author: N. Denaro, C. Lo Nigro, G. Natoli, E. G. Russi, V. Adamo, and M. C. Merlano

Source: https://www.hindawi.com/



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