Antibiotics and extracorporeal circulation – one size does not fit allReport as inadecuate

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Critical Care

, 18:695

First Online: 19 December 2014


Dosing of antibiotics in critically ill patients is a significant challenge. The increasing number of patients undergoing extracorporeal membrane oxygenation further complicates the issue due to inflammatory activation and to drug sequestration in the circuit. Since patients receiving extracorporeal membrane oxygenation commonly face severe infections, appropriate antibiotic selection and correct dosing is of paramount importance to improve survival. Therapeutic drug monitoring whenever available or population pharmacokinetics, based on readily available clinical and laboratory data, should help tailor antibiotic dosing to the individual patient.

AbbreviationsCRRTContinuous renal replacement therapy

ECMOExtracorporeal membrane oxygenation


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Author: João Gonçalves-Pereira - Bruno Oliveira



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