Association between toll-like receptors 9 TLR9 gene polymorphism and risk of pulmonary tuberculosis: meta-analysisReport as inadecuate




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BMC Pulmonary Medicine

, 15:57

Infectious, Rare and Idiopathic Pulmonary Diseases

Abstract

BackgroundPrevious studies indicated that the single nucleotide polymorphisms SNPs in TLR9 gene might be associated with Tuberculosis TB risk.
However, the results are inconsistent and inconclusive.

Methods1745 articles from four databases were involved in our study.
A meta-analysis on the associations between the seven polymorphisms and TB risk was carried out by comparison using different genetic models.

ResultsIn this systematic review 8 studies from seven English articles were analyzed.
Our results showed that rs352139 is significantly associated with TB risk AA vs.
AG, OR 0.77, 95% CI 0.65-0.92, P = 0.004.
In the ethnic subgroup analysis, Indonesians with AA genotype had a decreased susceptibility while Mexicans with GG allele had an increased risk.

ConclusionsThe meta-analysis indicated that rs352139 polymorphism might be associated with decreased TB risk in Indonesians whereas increased risk in Mexicans.
Whether the observed association was due to causal effect needs to be further studied.

KeywordsToll-like receptor 9 Polymorphism Tuberculosis Meta-analysis AbbreviationsTBTuberculosis

MTBMycobacterium Tuberculosis

TLRsToll-like receptors

PRRsPattern recognizing receptors

PAMPsPathogen-associated molecular patterns

LPSLipopolysaccharide

SNPsSingle nucleotide polymorphisms

CNKIChinese national knowledge infrastructure

HWEHardy-Weinberg Equilibrium

OROdds ratios

CIConfidence intervals

HGVSHuman genome variation society

pDCsPlasmacytoid dendritic cells

CpGCytosine-phosphate-guanine

TIRToll-IL-1 receptor

MyD88Myeloid differentiation factor 88

IRAK-4IL-1 receptor associated kinase 4

TRAF6Tumor necrosis factor receptor associated factor 6

IКKInhibitor of nuclear factor kappa-B kinase

MAPMitogen-activated protein

IкBNuclear factor inhibiter

NF-кBNuclear factor kappa-B

ALAS1Aminolevulinate delta-, synthase 1

LDLinkage disequilibrium

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Author: Zhi Chen - Wei Wang - Jianqin Liang - Jinhe Wang - Shisheng Feng - Guangyu Zhang

Source: https://link.springer.com/



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