Comparison of palonosetron, granisetron, and ramosetron for the prevention of postoperative nausea and vomiting after laparoscopic gynecologic surgery: a prospective randomized trialReport as inadecuate




Comparison of palonosetron, granisetron, and ramosetron for the prevention of postoperative nausea and vomiting after laparoscopic gynecologic surgery: a prospective randomized trial - Download this document for free, or read online. Document in PDF available to download.

BMC Anesthesiology

, 15:121

First Online: 03 September 2015Received: 12 August 2013Accepted: 26 August 2015

Abstract

BackgroundSelective 5-hydroxytryptamine type 3 5-HT3 receptor antagonists are reported to have potent antiemetic effects for postoperative nausea and vomiting PONV. The purpose of this study was to prospectively evaluate the efficacy of palonosetron, granisetron, and ramosetron for the prevention of PONV in patients undergoing laparoscopic gynecologic surgery.

MethodsIn this prospective, randomized observational study, 105 healthy female patients who were undergoing laparocopic hystectomy under general anaesthesia were enrolled clinical trial number: NCT01752374, www.clinicaltrials.gov. Patients were divided into three groups: the palonostron 0.075 mg i.v.; n = 35, the granisetron group 3 mg i.v.; n = 35, and the ramosetron group 0.3 mg i.v.; n = 35. The treatments were given before the end of surgery. The incidence of PONV, severity of nausea-vomiting, and the use of rescue antiemetic requirements during the first 48 h after surgery were evaluated.

ResultsThe overall incidence of PONV was 33.3 % for this series. The number of complete responders at 48 h after the surgery was 21 60.0 % for palonosetron, 24 68.6 % for granisetron, and 26 71.4 % for ramosetron, representing no statistical difference P = 0.086.

ConclusionsThere were no significant differences in the overall incidence of postoperative nausea and vomiting and complete responders for palonosetron, granisetron and ramosetron group.

Trial registrationClinical trial number: NCT01752374, www.clinicaltrials.gov.

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Author: Won-Suk Lee - Kwang-Beom Lee - Soyi Lim - Young Gin Chang

Source: https://link.springer.com/







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