Different KCO and VA combinations exist for the same DLCO value in patients with diffuse parenchymal lung diseasesReport as inadecuate




Different KCO and VA combinations exist for the same DLCO value in patients with diffuse parenchymal lung diseases - Download this document for free, or read online. Document in PDF available to download.

BMC Pulmonary Medicine

, 15:100

First Online: 03 September 2015Received: 23 January 2015Accepted: 29 July 2015

Abstract

BackgroundDLCO is the product of the CO transfer coefficient KCO by the -accessible- alveolar volume VA. In theory, the same DLCO may result from various combinations of KCO and VA values, each of which reflect different injury sites and mechanisms. We sought to determine in this study the potential variability of both VA and KCO for fixed values of DLCO in diffuse parenchymal lung diseases DPLD.

MethodsTo this end, we designed a retrospective, cross-sectional study of three distinct types of DPLD and analysed pulmonary function test PFT datasets.

ResultsWe show here that for the same value of DLCO 50 % predicted, KCO varied from 60 to 95 % predicted and VA from 55 to 85 % predicted in various types of DPLD idiopathic pulmonary fibrosis, sarcoidosis and connective tissue disease-associated DPLD, indicating distinct pathogenic mechanisms in these diseases. In addition, a comparison of VA with total lung capacity may help to evidence the distal airway obstruction sometimes associated with certain DPLD particularly sarcoidosis.

ConclusionClinicians should take into account not only DLCO but also VA and KCO values when managing patients with DPLD.

KeywordsCarbon monoxide diffusing capacity DLCO Carbon monoxide transfer coefficient KCO Interstitial lung disease AbbreviationsDLCOcarbon monoxide diffusing capacity

KCOrate for carbon monoxide uptake

VAalveolar volume

DPLDdiffuse parenchymal lung disease

IPFidiopathic pulmonary fibrosis

CTD-ILDsconnective tissue disease-associated interstitial lung diseases

PFTpulmonary function test

SDSstandard deviation score

FVCforced vital capacity

FEV1forced expiratory volume in 1 second

FRCforced respiratory capacity

TLCtotal lung capacity

sRawspecific airway resistance

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Author: Jean Pastre - Laurent Plantier - Carole Planes - Raphaël Borie - Hilario Nunes - Christophe Delclaux - Dominique Israël-B

Source: https://link.springer.com/



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