RNAi in the regulation of mammalian viral infectionsReport as inadecuate

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BMC Biology

, 10:58

First Online: 26 June 2012Received: 10 April 2012Accepted: 22 June 2012DOI: 10.1186-1741-7007-10-58

Cite this article as: Jeang, KT.
BMC Biol 2012 10: 58.


Although RNA interference RNAi is known to play an important part in defense against viruses of invertebrates, its contribution to mammalian anti-viral defense has been a matter of dispute.
This is surprising because all components of the RNAi machinery necessary for robust RNAi-mediated restriction of viruses are conserved in mammals, and the introduction of synthetic small interfering RNAs siRNAs into cells efficiently silences the replication of viruses that contain siRNA complementary sequences in those cells.
Here, I discuss the reasons for the dispute, and review the evidence that RNAi is a part of the physiological defense of mammalian cells against viral infections.

Electronic supplementary materialThe online version of this article doi:10.1186-1741-7007-10-58 contains supplementary material, which is available to authorized users.

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Author: Kuan-Teh Jeang

Source: https://link.springer.com/


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