An Indirect Atomic Absorption Spectrometric Determination of Trifluoperazine Hydrochloride in Pharmaceutical Formulations Based on Chelate Formation with PalladiumIIReport as inadecuate




An Indirect Atomic Absorption Spectrometric Determination of Trifluoperazine Hydrochloride in Pharmaceutical Formulations Based on Chelate Formation with PalladiumII - Download this document for free, or read online. Document in PDF available to download.

E-Journal of Chemistry - Volume 7 2010, S1, Pages S433-S441



University of Baghdad, College Science for Women Department of Chemistry, Jadiriyia, Baghdad, Iraq

Baghdad College of Pharmacy, Bab Al- Muadha-am, Baghdad, Iraq

Received 12 January 2010; Accepted 14 March 2010

Copyright 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A new application of an indirect atomic absorption spectrometric AAS method was offered for the assay of low concentration of trifluoperazine hydrochloride TFPH in pure and pharmaceutical dosage form with good accuracy and precision. The method is depended on the formation of metal complex between the drug TFPH and palladiumII to form orange-yellowish product extractable in organic solvent prior to its aspiration into an air-acetylene flame and indirectly determined by AAS. Using AA responses, all experimental parameters such as, pH, concentration of palladium, reaction time, extraction time and phase ratio which affect the complexation and extraction of TFPH-PdII, have been investigated. Under optimized conditions, linearity was observed in the range of 0.5-17 g mL

with detection limit S-N of 0.038 g mL

, precision in range of 1.18-1.92%, accuracy as the %Erel of 2.4% and recoveries ranged from 101.7 to 104% with mean value of 102.40.135. The proposed method was applied for the determination of TFPH in the drug stelazine by both direct calibration and standard additions procedures and found to be 4.88 and 4.87 mg per unite, respectively compared with the stated value of 5 mg per unite. This method is also compared statistically with direct determination by using UV-Vis spectrophotometric technique which is preformed in our laboratory and found to be insignificant at 95% confidence level. All statistical calculations were implemented via the chemsoftware Minitab version 11.





Author: Ameen W. Qasim and Zuhair A. A. Khammas

Source: https://www.hindawi.com/



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