KE and EE Genotypes of ICAM-1 Gene K469E Polymorphism Is Associated with Severe PreeclampsiaReport as inadecuate




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Disease Markers - Volume20142014, Article ID124941, 5 pages -

Research Article

Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Department of Obstetrics and Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Department of Pharmacology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Received 17 June 2013; Revised 18 October 2013; Accepted 2 December 2013; Published 30 January 2014

Academic Editor: EsperanzaOrtega

Copyright 2014 Ehsan Tabatabai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Preeclampsia PE is one of the most important complications of pregnancy that is associated with significant mortality and morbidity in mother and fetus. Since the etiologic factors in its development are still unclear, we aimed to examine the intercellular adhesion molecule-1 ICAM-1 gene K469E polymorphism in preeclamptic and control healthy women. Materials and Methods. Genetic polymorphism was analyzed in 192 PE and 186 healthy control women. PCR-RFLP method was used to identify K469E polymorphism. Results. The frequency of KK, KE, and EE genotypes of ICAM-1 gene was not different between PE patients and healthy pregnant women. Whereas, the frequency of KE and EE genotypes was significantly higher in severe PE than mild PE women and control group, and the risk of severe PE was 2.4-fold higher in subjects with KE genotype OR, 2.4 95% CI, 1 to 5.9; and 3.3-fold higher in subjects with EE genotype OR, 3.3 95% CI, 1.2 to 9; compared to individuals with KK genotype. Conclusion. We concluded that KE and EE genotypes of K469E polymorphism could increase risk of severe PE.





Author: Ehsan Tabatabai,Saeedeh Salimi,Milad Mohammadoo-khorasani,Minoo Yaghmaei,Mojgan Mokhtari,Farzaneh Farajian Mashhadi,and Anoosh Nag

Source: https://www.hindawi.com/



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