Risk factors of recurrence in small-sized, node negative breast cancer in young women: a retrospective study in Chinese populationReport as inadecuate




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Science China Life Sciences

, Volume 56, Issue 4, pp 335–340

First Online: 12 March 2013Received: 17 September 2012Accepted: 05 December 2012DOI: 10.1007-s11427-013-4435-y

Cite this article as: Zhang, X., Li, P., Ma, W. et al. Sci. China Life Sci. 2013 56: 335. doi:10.1007-s11427-013-4435-y

Abstract

We aimed to investigate risk factors of local and distant recurrence in small-sized, node negative breast cancer in women <35 years in a Chinese cohort. Between January 1994 and January 2007, 107 patients with pathologically confirmed small-sized ⩽1 cm, node negative breast cancer who did not receive neoadjuvant or adjuvant chemotherapy were included. The 5-year recurrence-free survival RFS was estimated according to different prognostic variables. With a median time of 60 months range, 8–60 months follow-up, local and distant recurrence were observed in 25 cases 23.4%. By univariate analysis, HER-2 positivity, triple negative TN, and high Ki-67 index ⩾14% were risk factors of a lower RFS hazard ratio HR 6.680, 95% confidence interval CI 2.350–18.985, P<0.0001 for HER-2 positive; HR 4.769, 95%CI 1.559–14.591, P=0.006 for TN; HR 6.030, 95%CI 2.659–13.674, P<0.0001 for high Ki-67 index. Patients with grade 3 tumors had a lower RFS HR 2.922, 95%CI 1.096–7.791, P=0.032 compared with those with grade 1 or grade 2 tumors. By multivariate analysis, HER-2 positivity HR 10.204, 95%CI 3.391–30.704, P<0.0001, TN HR 10.521, 95% CI 3.152–35.113, P<0.0001 and high Ki-67 index HR 10.820, 95%CI 4.338–27.002, P<0.0001 remained risk factors of RFS. In this cohort, HER-2 positivity, triple negative and high Ki-67 index were independent risk factors of RFS in young patients with T1a,bN0 breast cancer. Subsequent pregnancy did not affect RFS.

Keywordsbreast cancer recurrence-free survival risk factors young women Contributed equally to this work

This article is published with open access at Springerlink.com

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Author: XiaoSan Zhang - PengFei Li - WenJie Ma - WenYu Di - Shu Zhao - QingZu Gao - YuYing Zhao - MaoPeng Yang - QingYuan Zhang

Source: https://link.springer.com/







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